تفاعل #1005985

معادلة التفاعل

2-chloromethylquinoline hydrochloride

potassium carbonate

tert-butyl piperazine-1-carboxylate

→

2-(piperazin-1-ylmethyl)quinoline

المردود 92.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىReaction
2. 2
   ترشيحfiltered through celite
3. 3
   تركيزFiltrate was concentrated on Rotavapor under vacuum
4. 4
   أخرىthe crude residue was purified on SiO2 using Biotage SP1

الإجراء التجريبي

To a solution of 2-chloromethylquinoline hydrochloride (5 mmol) in anhydrous acetone (100 mL) was added, anhydrous potassium carbonate (15 mmol) and tert-butyl piperazine-1-carboxylate (7 mmol) and the reaction mixture was stirred under reflux conditions for 12 h. Reaction was cooled to r.t. and filtered through celite. Filtrate was concentrated on Rotavapor under vacuum and the crude residue was purified on SiO2 using Biotage SP1 to give a pure 2-(piperazin-1-ylmethyl)quinoline (6.3, 92%, pale yellow solid).

المصدر