تفاعل #1005972

معادلة التفاعل

2-bromo-2′-ethylsulfonylacetophenone

2-amino-4-trifluoromethylpyridine

→

2-(2-ethylsulfonylphenyl)-7-trifluoromethyl-imidazo[1,2-a]pyridine

المردود 26.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 1 hour
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   workup.ADDITIONA mixture of the residue, 250 mg of sodium bicarbonate and 1.5 ml of DMF
4. 4
   workup.ADDITIONWater was poured to the cooled reaction mixture
5. 5
   استخلاصthe mixture was extracted with ethyl acetate
6. 6
   غسيلThe organic layer was washed with water
7. 7
   تجفيفdried over anhydrous magnesium sulfate
8. 8
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

A mixture of 1.0 g of 2-bromo-2′-ethylsulfonylacetophenone, 334 mg of 2-amino-4-trifluoromethylpyridine and 4 ml of ethanol was refluxed for 1 hour and concentrated under reduced pressure. A mixture of the residue, 250 mg of sodium bicarbonate and 1.5 ml of DMF was stirred at 130° C. for 1 hour. Water was poured to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 190 mg of 2-(2-ethylsulfonylphenyl)-7-trifluoromethyl-imidazo[1,2-a]pyridine (hereinafter, referred to as Compound of Present Invention 8).

المصدر