تفاعل #1005957

معادلة التفاعل

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

المردود 95.2%

المذيبات

methanol

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted twice with ethyl acetate
2. 2
   غسيلwashed with water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   ترشيحThe desiccant was filtered
5. 5
   أخرىseparated
6. 6
   أخرىthe solvent was evaporated off under reduced pressure

الإجراء التجريبي

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

المصدر