تفاعل #1005944

معادلة التفاعل

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

4-fluoro-2-trifluoromethylbenzonitrile

potassium carbonate

N,N-dimethylformamide

→

title compound

المردود 42.5%

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

المردود 42.5%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling the mixture to room temperature
2. 2
   غسيلwashed with water three times
3. 3
   تجفيفThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   أخرىThe solvent was evaporated off under reduced pressure
5. 5
   أخرىthe residue was then purified by a column chromatography

الإجراء التجريبي

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g), 4-fluoro-2-trifluoromethylbenzonitrile (4.5 g) and potassium carbonate (5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred at 110° C. for 4 hours. After cooling the mixture to room temperature, the solution was diluted with ethyl acetate and washed with water three times. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (3.8 g).

المصدر