تفاعل #1005592

ord-b1f80ff7102e4fc786b2d7e146511d67

معادلة التفاعل

CC(=O)CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl
21 -chloro-11β,17-dihydroxy-16α-(2-oxopropoxy)pregna-1,4-diene-3,20-dione
CS(=O)(=O)Cl
methanesulfonyl chloride
Cl
hydrochloric acid
→
CC(=O)CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@@]1(O)C(=O)CCl
title compound
CC(=O)CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@@]1(O)C(=O)CCl
21-Chloro-17-hydroxy-16α-(2-oxopropoxy)-pregna-1,4,9(11)-triene-3,20-dione

المتفاعلات

CC(=O)CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl
21 -chloro-11β,17-dihydroxy-16α-(2-oxopropoxy)pregna-1,4-diene-3,20-dione
CS(=O)(=O)Cl
methanesulfonyl chloride
Cl
hydrochloric acid

الكواشف

لا شيء

المذيبات

CN(C)C=O
dimethylformamide
c1ccncc1
pyridine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    استخلاصextracted with chloroform
  2. 2
    تجفيفThe chloroform solution is dried
  3. 3
    أخرىevaporated

الإجراء التجريبي

A solution of 21 -chloro-11β,17-dihydroxy-16α-(2-oxopropoxy)pregna-1,4-diene-3,20-dione (10 mmoles) in 40 ml of dimethylformamide and 20 ml of pyridine is stirred at 0°C for 75 minutes with 10 ml of methanesulfonyl chloride. The mixture is poured into cold, dilute hydrochloric acid and extracted with chloroform. The chloroform solution is dried and evaporated to give the title compound.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US03971773uspto-grants-1976_07