تفاعل #10036

معادلة التفاعل

(2S,4R)-trans-4-hydroxyproline

formamide

hydrogen

→

title compound

المردود 92.1%

(2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid

المردود 92.1%

المذيبات

ethanol

water

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter removing the palladium on charcoal
2. 2
   ترشيحby filtration
3. 3
   أخرىthe water of the filtrate was removed by distillation under reduced pressure
4. 4
   أخرىThe solid residue thus obtained
5. 5
   أخرىThe crystals which precipitated
6. 6
   ترشيحwere collected by filtration

الإجراء التجريبي

A suspension of (2S,4R)-trans-4-hydroxyproline (5 g), 37% aqueous formamide solution (4.6 g) and 7.5% palladium on charcoal (53% water content, 3.2 g) in water (15 mL) was stirred at room temperature in an atmosphere of high-pressure hydrogen for 10 hours. After removing the palladium on charcoal by filtration, the water of the filtrate was removed by distillation under reduced pressure. The solid residue thus obtained was suspended and stirred in ethanol (25 mL). The crystals which precipitated were collected by filtration to give the title compound (5.1 g, yield 92%).

المصدر