تفاعل #1001833

ord-76ae13ba93db4ce78e8e70f1e9a58fcd

معادلة التفاعل

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
penicillin
CC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1
7-ADCA
Cl
HCl
NC(=O)C(N)c1ccccc1
D-phenylglycinamide
→
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
Cephalexin

المتفاعلات

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
penicillin
—
mixture
CC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1
7-ADCA
Cl
HCl
NC(=O)C(N)c1ccccc1
D-phenylglycinamide

الكواشف

لا شيء

المذيبات

—
aqueous solution

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىis carried out at 25° C.
  2. 2
    أخرىDuring the reaction

الإجراء التجريبي

The reaction is carried out at 25° C. and pH 7.5 in a fixed bed reactor. 10 ml of an aqueous solution of a mixture 0.2 M 7-ADCA and 0.2 M D-phenylglycinamide are passed through a column with 0.5 ml of the immobilized penicillin amidase. During the reaction, the pH is kept constant by adding HCl in an attached stirred reservoir container. Samples are taken and analyzed by HPLC as shown in example 5 at particular time intervals.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07264943B2uspto-grants-2007_09