تفاعل #1000754

ord-a7061e28db3b459a8f01e7a73e76ca6f

معادلة التفاعل

CCc1nc2c(Cl)c(C#N)ccc2[nH]1
4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile
FC(F)(F)c1cc(-c2nc(CCl)no2)cc(C(F)(F)F)c1
5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole
→
CCc1nc2c(Cl)c(C#N)ccc2n1Cc1noc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1
1-({5-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile

المتفاعلات

CCc1nc2c(Cl)c(C#N)ccc2[nH]1
4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile
FC(F)(F)c1cc(-c2nc(CCl)no2)cc(C(F)(F)F)c1
5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىSynthesized

الإجراء التجريبي

Synthesized as described in Example 197B from 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile and 5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole: MS (ESI) m/z 500 (M+1).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08026262B2uspto-grants-2011_09